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HelpTest Code LAB7045 Cytomegalovirus (CMV) Antibody, IgG and IgM, Serum
Infectious
Methodology
Multiple Flow Immunoassay
Literature Reference:
Package Insert: ToRC IgG package insert, Bio-Rad Laboratories, Inc. 04-2019
Package Insert: ToRC IgM package insert, Bio-Rad Laboratories, Inc. 08-2017
Performing Laboratory
Barnes-Jewish Hospital Laboratory
Specimen Requirements
Specimen Type: Serum
Container/Tube: Plain red top, Red/Grey SST or Gold SST
Specimen Volume: Full tube
Specimen Transport Temperature
Ambient
Reference Values
Referenve Values
CMV IgG - Negative
CMV IgM - Negative
Literature Reference:
Henry JB. Clinical diagnosis and management by laboratory methods. 20th ed. Saunders, 2001:765,1046-50,1057-58.
Day(s) Test Set Up
Monday through Sunday 0700-1300
Turnaround Time:
STAT: not available
Routine: results available the day of testing
Test Classification and CPT Coding
86644-CMV IgG
86645-CMV IgM
Additional Information
For BJH Laboratory Use Only
Laboratory Processing Instructions:
CMV IgG & IgM: Test performed in BJH Core Lab. Blood should be drawn aseptically. The serum should be separated and stored at 2° C to 8° C until tested but no longer than 7 days. The CMV test can also be performed on serum which was frozen at ≤-20° C. Do not use a frost-free freezer for storage due to the degradation of the antibody.
Interpretive Data
CMV IgG
|
Results |
Interpretation |
| Negative | Individuals with negative CMV IgG results are presumed to not have had prior exposure or infection with CMV and are, therefore, considered susceptible to primary infection |
|
Equivocal |
Equivocal results may occur during acute infection or may be due to nonspecific binding reactions. Submit an additional sample for testing if clinically indicated. |
|
Positive |
Indicates presence of detectable CMV IgG antibody. Results indicate past or recent CMV infection |
CMV IgM
|
Results |
Interpretation |
| Negative |
Negative CMV IgM results suggests that the patient is not experiencing acute or active infection. However, a negative result does not rule-out primary CMV infection. |
|
Equivocal |
Equivocal results may occur during acute infection or may be due to nonspecific binding reactions. Submit an additional sample for testing if clinically indicated. |
|
Positive |
Positive CMV IgM results may indicate a recent infection (primary, reactivation, or reinfection). |
Notes:
1. Positive results in neonates must be interpreted with caution.
2. Specimens drawn very early in the course of an infection may not have detectable level of IgG.
3. Patients with immunosuppression or recent blood transfusion must be interpreted with caution.
4. Performance characteristics have not been established for cord blood and neonates.
5. The results obtained from this assay are intended to be an aid to diagnosis only. Each physician must interpret the result in light of the patient’s history, physical findings and other diagnostic procedures.